1. Drive encryption has been flakey for me at best- I almost have that LONG recovery key memorized by now. I think I finally traced it to a USB drive that was accidentally left in during the encryption process coupled with problem #2. No issues for at least two days now- keeping my fingers crossed.
2. USB drivers were "updated" forcefully by MS after about two days. Despite the fact it could detect that they were not working correctly, it kept them. I manually rolled drivers back and USB is back to working. Lots of Internet chatter that drivers like to reinstall again later, so waiting to see if this crops up again.
3. Video seems to work fine on the laptop but the resolution and window placement is a bit wonky on my external monitor. Also, some "full screen" applications working in a borderless window but mouse is stuck inside the window like it actually is running full screen.
4. Have the dreaded unknown device showing up in device manager despite everything recognizing correctly before upgrade. I haven't had time to chase this one down yet.
5. Got a warning during upgrade that Bluetooth stack may not work correctly, but it seems to be working OK... so far
6. Have not yet tried WWAN as I am still trying to work out an issue with Verizon to get a working SIM card. Apparently my Ebay $40 wonder card came from a Panasonic tablet and their system cannot sell me the correct size SIM because it shows incompatible with the tablet. That reminds me, I need to call their tech support.
7. Edge is not working on a lot of web sites, but that is web page issue, not a CF-52 thing. I'm sure this will improve with time. At least TBT works.

8. I turned off the Windows Update file sharing because I am not particularly interested in subsidizing MS's bandwidth.
I'm sure there will be more issues later as I spend more time with this monster.